Angiogenesis

Question 1

Differences between arteries and veins

-location of the majority of blood

Answer 1

Thicker TM in artery
Wider lumen in vein

65% in veins
30% in arteries
5% in capillaries

Question 2

Neovascularisation periods

• normal
• pathological

Answer 2

Ovulation, menstruation, placenta formation

Wound healing
Retinal development - retinopathies

Tumours
RA, PsA

Question 3

Definitions of
-vasculogenesis
-angiogenesis
-arteriogenesis
When do these processes mainly happen

Answer 3

Vasculogenesis - new vessels from progenitors

• in embryogenesis
• mesoderm forms => blood islands form and fuse and differentiate, forming new vessels

Angiogenesis - new capillaries from existing ones

• hypoxia
• cells migrate towards VEGF and develop

Arteriogenesis - new arteries from existing ones
-fluid shear stress