MD2002 > ANS 2 > Flashcards

ANS 2 Flashcards

(39 cards)

Study These Flashcards
1
Q

what are the effects of anticholinesterases on the ANS?

A 
Salivation
Lacrimation
Urination
Defecation
Gastrointestinal upset
Emesis

Bradycardia
Bronchoconstriction
Hypotension
Pupillary constriction (miosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are predominate locations of nicotinic Ach receptors?

A
  • NMJ
  • sympathetic ganglia
  • parasympathetic ganglia
  • CNS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are predominate locations of muscarinic Ach receptors?

A
  • parasympathetic target organs
  • sweat glands (sympathetic)
  • vascular smooth muscle
  • CNS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

which agonists have specificity with muscarinic receptors?

A
  • acetylcholine
  • muscarine
  • bethanechol
  • pilocarpine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

which agonists have specificity with nicotinic receptors?

A
  • achetylcholine

- nicotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

which agonists do nicotinic and muscarinic Ach receptors share?

A

achetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the 3 classes of muscarinic Ach receptors?

A
  1. M1 (neural)
  2. M2 (cardiac)
  3. M3 (glandular/smooth muscle)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the main locations of M1 (neural) Ach receptors?

A

autonomic ganglia glands:

  • gastric
  • salivary
  • lacrimal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the main locations of M2 (cardiac) Ach receptors?

A
  • heart

- atria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the main locations of M3 (glandular/smooth muscle) Ach receptors?

A

exocrine glands:

  • gastric
  • salivary

smooth muscle:

  • GI tract
  • eye
  • airways
  • bladder

blood vessels:
- endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the cellular response of M1 Ach receptors?

A

↑ IP3, DAG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the cellular response of M2 Ach receptors?

A

↓ cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the cellular response of M3 Ach receptors?

A

↑ IP3, DAG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the functional response of M1 Ach receptors?

A

gastric secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the functional response of M2 Ach receptors?

A

cardiac inhibition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the functional response of M3 Ach receptors?

Study These Flashcards
A
  • gastric, salivary secretion
  • GI smooth muscle contraction
  • ocular accommodation
  • vasodilation
17
Q

what are the pharmacological properties of pilocarpine?

Study These Flashcards
A

non-selective muscarinic agonist

18
Q

what are clinical uses of pilocarpine?

Study These Flashcards
A
  • constriction of pupils (miosis)
  • glaucoma (to decrease IOP)
  • xerostomia (following head/neck radiotherapy)
19
Q

what are the pharmacological properties of bethanechol?

Study These Flashcards
A

non-selective muscarinic agonist

20
Q

what are the pharmacological properties of atropine?

Study These Flashcards
A
  • non-selective agonist
  • well absorbed orally
  • CNS effects
21
Q

what type of receptor is a muscarinic receptor?

Study These Flashcards
A

g-protein linked receptor (metabotropic)

22
Q

what type of receptor is an nicotinic receptor?

23
Q

what does acetylcholine have receptor specificity for?

Study These Flashcards
A

muscarinic and nicotinic

24
Q

what does nicotine have receptor specificity for?

25
what does muscarine have receptor specificity for?
muscarinic
26
what does bethanechol have receptor specificity for?
muscarinic
27
what does pilocarpine have receptor specificity for?
muscarinic
28
what are the clinical uses of bethanechol?
bladder and gastrointestinal hypotonia
29
what are the clinical uses for atropine?
- adjunct for anaesthesia - anticholinesterase poisoning - bradycardia/cardiac arrest
30
what are the pharmacological properties of glycopyrronium?
similar to atropine: - non-selective agonist - wel absorbed orally - CNS effects - does not cross blood brain barrier
31
what are the clinical uses of glycopyrronium?
- adjunct for anaesthesia - anticholinesterase poisoning - bradycardia/cardiac arrest
32
what are the pharmacological properties of hyoscine hydrobromide?
similar to atropine: - non-selective agonist - wel absorbed orally - CNS effects
33
what are the clinical uses of hyoscine hydrobromide?
- hypersalivation | - motion sickness
34
what are the pharmacological properties of ipratropium?
- delivered via inhaler or nebuliser | - does not cross blood brain barrier
35
what are the clinical uses of ipratropium?
maintenance treatment of COPD
36
what are pharmacological properties of tropicamide?
similar to atropine but shorter acting: - non-selective agonist - well absorbed orally - CNS effects
37
what are clinical uses of tropicamide?
opthalmic use (mydriasis)
38
why is there little therapeutic uses for agonists?
very few diseases of decreasing parasympathetic activity, more due to increasing activity
39
what are the general problems of selectivity with antagonists?
- few differentiate between subtypes effectively - muscarinic ACh receptors widespread; side effects - control by route of administration and distribution
MD2002
flashcards
Decks in class (85)
# Cards
Brainscape helps you reach your goals faster, through stronger study habits.
© 2026 Bold Learning Solutions. Terms and Conditions