Antagonists

Question 1

Naloxone - Dose/Timing

Answer 1

• 0.1-0.2 mg IV q 2-3 min
• Onset: 1-2 min
• Peak: 5-15 min
• Duration: 30-45 min

Question 2

Naloxone - Indications

Answer 2

• Narcotic Antagonist
• Reverses opioid induced depression/sedation
• *** IV Naloxone administration for respiratory depression requires the patient to remain in PACT 60 min post administration and anesthesiologist must be consulted prior to discharge
• May also be given for opioid induced pruritis (smaller dosage)

Question 3

Naloxone - Adverse Effects

Answer 3

• Shorter duration of action than many opioids
• Important to watch for rebound effects of the opioid
• Tachycardia
• Hypo/hypertension
• Nausea

Question 4

Flumazenil - Dose/Timing

Answer 4

• 0.2 mg IV q 1 min to max 1 mg
• Onset: 1-2 min
• Peak: 6-10 min
• Duration: 45-90 min

Question 5

Flumazenil - Indications

Answer 5

• Benzodiazepine antagonist

* Reversal of benzodiazepine induced sedation

Question 6

Flumazenil - Adverse Effects

Answer 6

• Nausea
• Agitation
• Seizures