Nucleus of cephalosporins
7-aminocephalosporanic acid
Cephalosporins not active against:
Enterococci
L. monocytogenes
Cephalosporin dosage adjustment in liver failure?
No, most cleared renally
Cephalosporin 1st gen prototype
Cefazolin (IV, IM)
1st gen cephalosporins poor activity against
P aeruginosa Indole-positive proteus species Enterobacter sp S marcescens Citrobacter sp Acinetobacter sp
2nd gen cephalosporin prototype
Cefuroxime (iv, oral)