Fluoroquinolone MOA
Inhibition of DNA gyrase (topoisomerase II)
required for bacterial DNA replication, transcription, repair and recombination
Penicillin G
Beta-lactam
Penicillin G spectrum
Gram +
Not Staphylococcus spp
Anaerobes
Not Bacteriodes spp
Penicillin G pharmacokinetics
Time-dependent
Cidal
Water soluble - distributed via ECF
Penicillin G MOA
Irreversibly binds PBD - intervening with cell wall peptidoglycans - cell lysis