Anticoagulation

Question 1

What drug is used for a prophylactic dose of anticoagulation in VTE?

Answer 1

LWMH (dalteparin)

Question 2

What drug may be used for a prophylactic dose of anticoagulation in VTE in a patient with renal failure?

Answer 2

Unfractionated heparin

Question 3

What class of drug is given for a treatment dose of anticoagulation in patients with VTE? Give two examples

Answer 3

DOACs

(Apixaban and Rivaroxaban)

Question 4

What is used to monitor LWMH and what is the reversal agent of this class of drugs?

Answer 4

• Anti-factor Xa
• Protamine sulphate

Question 5

What is used to monitor unfractionated heparin and what is its reversal agent?

Answer 5

• aPTT
• protamine sulphate

Question 6

What monitoring is required for DOACS and what are their reversal agents?

Answer 6

• None
• Andexanet alpha (apixaban and rivaroxaban)
• Idarucizumab (dabigatran)

Question 7

What is used to monitor warfarin and what is its reversal agent?

Answer 7

• INR
• Vitamin K (phytomenadione)