Anticoagulation Workshop

Question 1

infications for anticoagulation

Answer 1

(VENOUS AND ARTERIAL THROMBOTIC DISEASE)
- AF
- DVT
- PE
- Artificial heart valve replacement

Question 2

what is Virchows triad how each factor occurs

Answer 2

FACTORS CONTRIBUTING TO THROMBOSIS

1. endothelial trauma (
2. venostasis (altered venous blood flow - maybe faulty valves)
3. hypercoagulation

Question 3

causes of hypercoagubility

Answer 3

• AT III Protein C and S deficiency
• malignancy
• dysfibrinolysis
• hyperhomocysteinemia
• elevated Factor VIII(8)
• diabetes 1 and 2

Question 4

most common CVD

Answer 4

coronory artery disease (CAD)

Question 5

If DVT is suspected, use the ?
to estimate the clinical probability of DVT

Answer 5

2-level DVT Wells score
DVT likely >2
PE likely >4

Question 6

classic presentation of DVT

Answer 6

unilateral DVT (swelling on one side)
blockage of blood vessels and hot to touch due to inflammatory markers

Question 7

is AF more likely in men or women

Answer 7

men

Question 8

risk assesment tools in AF

Answer 8

CHADSVASc Score
(anticoagulation should happen if score >2)
ORBIT Bleeding risk scoring system
HAS-BLED

Question 9

what factors does ORBIT measure

Answer 9

Older (>75yrs)
Reduced haemoglobin
Bleeding history
Insufficient kidney function
treatment with antiplatelt agent

better predictability than ATRIA and HAS-BLED

Question 10

what factors does HAS-BLED measure

Answer 10

1 point each for:
Hypertension
Abnormal renal/liver function (1 for each)
Stroke
Bleeding history or predisposition
Labile INR
Elderly (age over 65)
Drugs*/alcohol** concomitantly (1 for each)

Question 11

What key event occurs around factor X?

Answer 11

extrinsic and intrisic pathway converge
- on activation convertes Prothrombin to thrombin

Question 12

when do we use dual antiplatelt therapy

Answer 12

after placement of stent(s) in your coronary arteries, after coronary artery bypass surgery (CABG) or heart valve surgery
or a heart attack