Antidepressants

Question 1

TCA toxicity causes what? (9)

Answer 1

Torsades
Arrhy
Severe hypoTN
Agitation/delirium
Seizures
Very high fever
Coma/shock
Metabolic acidosis
Respiratory depression

Question 2

TCA toxicity tx? (4)

Answer 2

Gastric lavage + activated charcoal
Mg + isoproterenol (for torasdes)
Lido, propranolol, pheny (arrhy, seizure)
Sodium bicarb, KCl (acidosis)

Question 3

MAO-A metabolizes?

Answer 3

NE and 5HT in CNS and GI

Question 4

MAO-B metabolizes?

Answer 4

DA in CNS

Question 5

Serotonin Syndrome is?

Answer 5

Overstim of 5HT receptors

Cognitive sxs: delirium, convulsion, coma

Autonom sxs: HTN, tachy

Somatic sxs: myoclonus, high fever