1
Q
Imipramine
A
TCA
2
Q
Amitriptyline
A
TCA
3
Q
Desipramine
A
TCA
4
Q
Nortriptyline
A
TCA
5
Q
Clomipramine
A
TCA
6
Q
Maprotoline
A
TCA
7
Q
Tranycypromine
A
MAOI
8
Q
Phenelzine
A
MAOI
9
Q
DI with MAOIs
A
Phenylpropanolamine, pseudoephedrine, meperidine
10
Q
Selegiline
A
MAOI (B more than A)
11
Q
Fluoxetine
A
SSRI
12
Q
Paroxetine
A
SSRI
13
Q
Sertraline
A
SSRI
14
Q
Citalopram
A
SSRI
15
Q
Escitalopram
A
SSRI
16
Q
Venlafaxine
A
SNRI
17
Q
Desvenlafaxine
A
SNRI
18
Q
Duloxetine
A
SNRI
19
Q
Levomilnacipran
A
SNRI
20
Q
Bupropion
A
Mixed Action
21
Q
Mirtazapine
A
Mixed Action
22
Q
Trazodone
A
Mixed Action
23
Q
Vilazodone
A
Mixed Action
24
Q
Vortioxetine
A
Mixed Action
25
1st generation antidepressants
TCAs and MAOIs
26
2nd generation antidepressants
SSRIs, SNRIs, Mirtazapine, Bupropion
27
TCA CIs
BPH, arrhythmias, narrow angle glaucoma, dementia
28
TCA OD
lethal (cardiotoxic)
29
Amitriptyline AEs
Anticholinergic, sedation, cardiotoxic
30
Imipramine AEs
orthostatic hypotension, cardiotoxic
31
TCA class AEs
anticholinergic, sedation, orthostatic hypotension, cardiotoxic, lower seizure threshold, weight gain
32
Clomipramine max dose
250 mg due to seizure risk
33
Serum drug concentrations with these antidepressants
TCAs (1 wk stable dose - trough 12 hours after last dose)
34
SSRI and MAOI washout period
14 days, except Fluoxetine which is 5 weeks (long t1/2)
35
"Cheese Reaction" symptoms
BP 220/130, HA, flushing, palpitations, diaphoresis, N/V
36
SSRI AEs
Short term: HA, N/D, increased anxiety
| Long term: weight gain, sexual dysfunction
37
Citalopram max dose
40 mg qd due to QT prolongation
38
Paroxetine AEs:
mild anticholinergic (avoid elderly), discontinuation syndrome (worst - requires tapering)
39
Least discontinuation syndrome of SSRIs
Fluoxetine (no tapering needed)
40
SSRI DIs
```
Most with fluvoxamine, fluoxetine, sertraline
(class DI with tramadol and linezolid)
```
41
Serotonin syndrome symptoms
(due to result of overstimulation of 5-HT1a) TRIAD: mental, autonomic, neurological - confusion, agitation, insomnia, fever, diaphroesis, myoclonus, tremor, hyperreflexia, cardiovascular collapse, coma, death
42
Serotonin syndrome treatment
5-HT2A #s (cyproheptadine, olanzapine)
43
SSRI AEs
Lethality, insomnia, anticholinergic, sexual dysfunction, increased blood pressure (don't give venlafaxine, levomilnacipran to uncontrolled HTN patients), discontinuation syndrome (venlafaxine)
44
Bupriopion AEs
Moderate agitation (peps people up), seizures (avoid if eating disorders or epilepsy)
45
Mirtazapine and Trazodone AEs
severe sedation
46
Trazodone AEs:
orthostasis, pripaism
Antidepressants
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