antifungal

Question 1

what are the different types of fungal pathogens/infections?

Answer 1

• thrush
• oral thrush
• athletes foot
• toe nail infection
• dandruff

Question 2

what are the drug targets for antifungal tgherapy?

Answer 2

• cell membrane
• DNA synthesis
• cell wall

Question 3

what does fungals have in the cell wall that plays a key role?

Answer 3

-ergosterol

Question 4

what enzye can be inhibited to prvent ergosterol prodcution?

Answer 4

lanosterol 14a-demethylase

Question 5

what drug is used to inhibit lanosterol 14a-demethylase?

Answer 5

azoles

Question 6

what is the mode of action?

Answer 6

multi-step process most involving a cytochrme P450 enzyme co factor.

Question 7

where does azole bind to in teh cytochrome?

Answer 7

the iron in the enzyme

Question 8

why is monotherapy limited now for flucytosine in clinical uses?

Answer 8

because it can cause resistance