Antifungals Flashcards by Matt Seiffert

Q

Interferes with microtubule formation

A

griseofulvin

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Q

Swish and swallow for oral candidiasis

A

nystatin

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Q

Cell wall synthesis inhibitor used in invasive aspergillosis

A

caspofungin

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Q

Binds ergosterol, creates membrane pores (2)

A

nystatin

amphotericin B

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Q

Inhibits ergosterol synthesis (2)

A

azoles

terbenifene

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Q

Most common treatment for onychomycosis (2)

A

terbenipene

griseofulvin

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Q

Side effects: arrhythmias and nephrotoxicity

A

amphotericin B

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Q

Deposits in keratin-containing tissues

A

griseofulvin

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Q

Inhibits hormone synthesis and cytochrome P450

A

azoles

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Q

Side effect: liver dysfunction (2)

A

azoles

griseofulvin

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Q

Side effects: teratogen, carcinogen

A

griseofulvin

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Q

Used for cryptococcal meningitis in AIDS (2)

A

fluconazole

intrathecal amphotericin b

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Q

Converted to fluorouracil, inhibits DNA synthesis

A

flucytosine

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Q

Drug of choice for sporotrichosis

A

itriconazole

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Q

Used intrathecally for fungal meningitis

A

amphotericin b

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Q

Clinical use of griseofulvin

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A

superficial fungal infections

tinea capitis/ungium

Q

Side effects of griseofulvin (4)

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A

teratogenic
carcinogenic
induces p450
hepatotoxic