methods of determining MIC
broth dilution, E test gradient, disk diffusion
category I antimicrobials
shouldn’t use unless have to, consult expert
category II antimicrobials
consider when no alternatives
category III antimicrobials
ideal for empirical and culture-directed treatments
good tissue penetration abx
chloramphenicol, fluoroquinolone, sulfonamides, clindamycin
make time dependent more effective
give more frequently
make concentration dependent more effective
give larger dose