Naming convention: - TREX
folate analogues
METHOTREXATE (inhibits DHFR), PEMETREXED,
PRALATREXATE (inhibit thymidylate synthase)
Naming convention: CITABINE and ARABINE
Antimetabolites: inhibit DNA pol, and Ribonucleotide reductase (fludarabine)
CAPECITABINE, CLADARABINE,
CYTARABINE, FLUDARABINE,
GEMCITABINE
Naming convention: -PLATIN
platinum cross-linking agents
CISPLATIN, CARBOPLATIN,
OXALOPLATIN
Naming convention: -RUBICIN
Anthracycline antibiotics: intercalate DNA
DAUNORUBICIN, DOXORUBICIN,
EPIRUBICIN, IDARUBICIN
Naming convention: -MUSTINE
nitrosoureas: alkylating agents, cross link DNA
CARMUSTINE (BCNU), LOMUSTINE
CCNU
Naming convention: -TAXEL
taxanes: promote spindle growth
PACLITAXEL, CABAZITAXEL,
DOCATAXEL
Naming convention: -MYCIN
antibiotics: DNA strand breaks
BLEOMYCIN, MITOMYCIN
Naming convention: -TECAN
Camptothecins = topo I inhibitors, strand breaks
IRINOTECAN, TOPOTECAN
Naming convention: VIN…..INE
vinca alkyloids: inhibits spindle synthesis
VINBLASTINE, VINCRISTINE,
VINORELBINE
- Prevent DNA synthesis
- Block nucleotide synthesis (both purines and pyrimidines)
- Inhibit dihydrofolate reductase
Methotrexate
Pemetrexed
Pralatrexate
- Prevent DNA synthesis
- Block purine synthesis
- “Pseudofeedback inhibition” of PNP and PRPP
6-Mercaptopurine
6-Thioguanine
- Prevent DNA synthesis
- Block pyrimidine synthesis
- Inhibit thymidylate synthase
Capecitabine
5-Fluorouracil
Pemetrexed
Pralatrexate
-Prevent DNA synthesis
-Block generation of deoxyribonucleotides
Inhibit ribonucleotide reductase
Cytarabine
Fludarabine
Gemcitabine
Hydroxyurea
- Prevent DNA synthesis
- Block DNA synthesis
- Inhibit DNA polymerase
Cladarabine
Cytarabine
Fludarabine
Gemcitabine
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Crosslink DNA
- Alkylating agents
Busulfan Carmustine (BCNU) Chlorambucil Cyclophosphamide Dacarbazine Ifosfamide Lomustine (CCNU) Mechlorethamine Melphalan Mitomycin Procarbazine Temozolamide
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Intercalate or form adducts with DNA
- Anthracycline antibiotic (and related agents)
Daunorubicin Doxorubicin Epirubicin Idarubicin Mitoxantone
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Cause DNA strand breaks
- Free radical generation
Bleomycin
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Cause DNA strand breaks
- Form topoisomerase II-DNA complexes
Etoposide
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Cause DNA strand breaks
- Inhibit topoisomerase I
Irinotecan
Topotecan
- Disrupt DNA, prevent DNA repair and/or interfere with RNA synthesis
- Cause DNA strand breaks
- Generate H2O2 (??)
Procarbazine
- Interrupt mitosis
- Disrupt spindle formation
- Terminate spindle assembly
Vinblastine
Vincristine
Vinorelbine
Interrupt mitosis
- Disrupt spindle formation
- Enhance spindle formation
Paclitaxel
Ixabepilone
