Serotonin SE
EPS
Sexual dysfunction
Weight gain
Dopamine SE
Neurological
Hyperprolactinemia
QTc prolongation
Histamine SE
sedation
cholesterol/weight gain
Anticholinergic (NA) SE
constipation
blurred vision
dry mouth
Alpha 2 SE
postural HTN
Rare antipsychotic side effects
agranulocytosis
neuromalignant syndrome
cholestasis
ocular pathology
First generation/typical antipsychotics
Chlorpromazine
Haloperidol
Pericyazine
Zuclopenthixol
Atypical antipsychotics
Clozapine
Risperidone
Paliperidone
quetiapine
amisulpride
3rd Generation antipsychotics
aripiprazole
Signs of EPS
ADAPT =
Acute Dystonia
Akathisia
Parkinsonism
Tardive dyskinesia
Signs of Neuroleptic Malignant Syndrome
fever
gross CK elevation
muscle rigidity
mental status change
autonomic instability
rhabdomyolysis
Risperidone/paliperidone SE
high prolactin
Haloperidol indication
amphetamine-induced psychosis
Why should you not change smoking habits on clozapine
smoking lowers blood concentration of clozapine - suddenly stopping will increase levels –> respiratory arrest (aka if you stop smoking randomly you will die)
clozapine rebound psychosis
Why is clozapine last-line
cholinergic side effects
weight gain
hypotension if fast titration
severe constipation
Clozapine SE
agranulocytosis
neutropenia
myocarditis
nocturnal hypersalivation
hypotension (sedation, dizziness)
What receptor do antipsychotics mainly work on
D2
