antipsychotics

Question 1

low potency typical antipsychotics list

Answer 1

chlorpromazine

thioridazine

Question 2

high potency typical antipsychotics list

Answer 2

haloperidol

fluphenazine

Question 3

atypical antipsychotics group 1 list

Answer 3

Olanzapine
risperidone 
paliperidone, 
iloperidone
quetiapine, 
clozapine

Question 4

atypical antipsychotics group 2 list

Answer 4

ziprasaidone
aripiprazole
lurasidone

Question 5

more atypical antipsychotics list

Answer 5

asenapine
iloperidone
brexpiprazole
cariprazine

Question 6

mood stabilizer antiseizure drug list

Answer 6

valproate
lamotrigine
carbamazepine
lithium

Question 7

chlorpromazine

Answer 7

lots of sedation
and adverse effects 
hold back neurological processing 
good for positive symptoms 
bad because movement disorder

Question 8

thioridazine

Answer 8

extensive 1st pass metabolist
good for positive symptoms
bad because cardiotoxicity and retinopathy

Question 9

haloperidol use

Answer 9

initial antipsychotic for rapid onset in acute psychosis
also maintenance therapy for pts refractory to other antipsychotics
Strong D2 receptor inhibitor

Question 10

side effects of haloperidol

Answer 10

extrapyramidal toxicity
very little hypotension
low rates of metabolic effects
low sedation rates

Question 11

extrapyramidal adverse effects

Answer 11

acute dystonia and parkinsonism onset early

tradive dyskinesia occur late

Question 12

treatment of tardive dyskinesea

Answer 12

switch to an atypical agent
early recognition and lowest dose
reducing dose or chaning to low risk drug is best long term

Question 13

fluphenazine

Answer 13

sedating but avalible in long lasting injections

postive symptoms

Question 14

uses of group 1 atypical antipsychotics

Answer 14

good for postive and negative symptoms

low risk for movement disorders

Question 15

risperidone

Answer 15

low extrapyramidal toxicity; cheapest of all atypical antipsychotics low risk for TC
FDA for MDD

Question 16

side effects of group 1 atypical antipsychotics

Answer 16

metabolic side effects
weight pain
worsening lipid profile
dm or Cv disease development

Question 17

clozapine use

Answer 17

clozaptine first atypical drug important role in txtment of schziophrenia refractory to other txtment

Question 18

clozapine advantages

Answer 18

low risk for extrapyramidal toxicity
low rates of sedation
may effective in txtment of refractor schizophrenia

Question 19

clozapine disadvantages

Answer 19

agranulocytosis
seizures
myocarditis
orthostatic hypotension

requires CBC monitoring

Question 20

black box for all antipsychotics

Answer 20

increased momrtality in elderly dementia patients on conventional or atypical antipsychotics due to CV or infectious events

Question 21

group 2 benefits

Answer 21

low risk of weight gain and low risk of extrapyramidal side effects

Question 22

moa of ziprasidone

Answer 22

D2 antagonists and NE reuptake inhibitor and is weight neutral
take with food

Question 23

aripiprazole

Answer 23

lower rates of weight gain and lipid disorders than group 1 but slightly higher than ziprasidone

Question 24

Aripiprazole and ziprasidone are more commonly used as

Answer 24

mood stabilizers or for other various behavioral therapies than for schizophrenia

Question 25

aripiprazole FDA approval

Answer 25

for adjunct for MDD with an SSRI

Question 26

Lurasidone and ziprasidone must be taken with a

Answer 26

meal to maximize oral bioavailability

Question 27

use of lamotrigine

Answer 27

antiseizure med good for depressive phase of bipolar; acute mania and prophylaxisi of manis

Question 28

use of carbamzepine

Answer 28

bipolar acute mania prophylaxisi of acute mania

Question 29

use of valpromate

Answer 29

acute mania combo with lithim

Question 30

use of lithium

Answer 30

acute mania | used as maintenance of decrease frequency and severity of swing between depression and mania

Question 31

what reduces lithium clearance

Answer 31

renal clearance reduced by diuretics acei arbs nsaids so must monitor serum lithium levels

Question 32

s/s of lithium tox

Answer 32

Minor toxicity begins at levels between 1 to 2 mEq/L Diarrhea, vomiting, drowsiness, muscular weakness, and a lack of coordination. Moderate toxicity between 2 to 3 mEq/L Giddiness, blurred vision, ataxia, tinnitus, copious dilute urine. Major toxicity if over 3 mEq/L High morbidity. May require IV fluids and hemodialysis, depending on the clinical situation.

Question 33

ADE of lithium

Answer 33

tremor, increased thirst, edema

Question 34

causes of TD

Answer 34

D2 hypersensitivity

Question 35

neuroleptic malignant syndrome symptosm

Answer 35

``` fever regitidty AMS autonomic dysfunctiion tachy tachypnea incontinence ```

Question 36

Carbamazepine and lamotrigine are both used in

Answer 36

acute mania and for mania prophylaxis during euthymic or depressive phases