APAS

Question 1

Patients who test positive for all 3 of these diagnostic tests are at higher risk for thromboembolic events

Answer 1

1. LUPUS ANTICOAGULANT
2. ANTICARDIOLIPIN ANTIBODIES
3. β2-GLYCOPROTEIN ANTIBODIES

Question 2

What drug is used in symptomatic patients with APL antibodies but no evidence of thrombotic events or the APS?

Answer 2

ASPIRIN (Low dose)

Question 3

What is the threrapeutic regimen used in patients with full APS?

Answer 3

ANTICOAGULATION WITH:
• HEPARIN –> followed by WARFARIN

Question 4

What drugs are used in pregnant patients with APS?

Answer 4

1. HEPARIN
2. ASPIRIN (low dose)

Question 5

What 3 therapies are used in patients who cannot tolerate anticoagulation due to recent bleeding, who have thromboembolic events despite adequate anticoagulation, or who have catastrophic APS?

Answer 5

PLASMAPHERESIS + CORTICOSTEROIDS + IMMUNOSUPPRESSIVES