3 hypothalamic nuclei, what are they
arcuate nucleusus, lateral hypothalamic area, paraventricular nucleus
arcuate nucleus
Lateral hypothalamic area
Responsible for search for food, initiation and stimulation of eating (search for food)
Paraventricular nucleus
orexigenic
promotes eating
anorexigenic
stops eating
NPY/AGRP
promotes food intake
POMC/CART
suppresses food intake
leptin
exerts its effects through leptin receptor, inhibits NPY/ AGRP neurons and stimulates POMC/CART neurons (satiety)
insulin
inhibits NPY/AGRP neurons and stimulates POM/CART neurons (satiety)
peptide YY
Inhibitory effect on the NPY/AGRP neurons so its anorexigenic (satiety)