ARBs

Question 1

MOA

Block angiotensin II binding w/type I angiotensin II receptors

Block vasoconstriction & secretion of aldosterone

Answer 1

Have a decreased risk of nonproductive cough & hyperkalemia than ACE inhibitors

Question 2

Contraindications/precautions

• Drug allergy
• Pregnancy
• Renal disease
• Elderly

Question 3

Adverse effects

• HA, dizziness
• Nasal congestion, fatigue, respiratory infection
• Heartburn, cough, diarrhea, insomnia, angioedema, muscle pain

Question 4

Nursing

• Do not stop abruptly
• Report SOB, wt gain, CP, palps
• Report dizziness, orthostatic hypotension; may reduce dose r/t hypovolemia & hepatic dysfunction

Question 5

Examples

___(Cozaar) & ___ (Diovan)

Answer 5

losartan, valsartan