Aspergillus

Question 1

type

Answer 1

Filamentous
conidiophore
SPhericalasexual
reproductive
structures

Question 2

transmission and risk factors

Answer 2

Worldwide
- decaying
matter, air &
soil
- outcome of
infection is
strongly
dependent on
host factors

Question 3

presentation

Answer 3

Sx:
- Deadly invasive
pneumonia
- Hemoptysis
- High mortality

Question 4

the 2 forms of aspergillus

Answer 4

1. Allergic: asthma,
   CF - ABPA inhale
   spores→ HS rxn →
   exacerbated in Asthma
   - 2. Invasive: hyphae
   invade tissue in
   transplant pts(lung)

Question 5

pathogenesis

Answer 5

• Formation of fungal
  ball(Aspergilloma) →
  necrotizing,
  bronchiectasis,
  secondary TB. Does
  not invade → if it
  invades then
  hemoptysis
• Acute pneumonia in
  severely
  immunocompromise
  d (transplant) e.g.
  NEUTROPenia

Question 6

diagnostic

Answer 6

“Branching tree
like pattern”
Septate hyphae