associations

Question 1

HCV

Answer 1

metabolic synd, insulin resistance, NAFLD

Question 2

Keratocystic odontogenic tumor

Answer 2

Gorlin synd (basal cell carcinoma) (mutations on PTCH gene)

Question 3

Hirschprung’s Dis

Answer 3

DS and neuro abns

Question 4

Peutz-jeghers syndrome

Answer 4

• malignancies to testes, gastric/SI, colon, pancreatic, breast, lung, ovarian and uterine cancers.
• intussusception

Question 5

cholelithiasis

Answer 5

• acute cholecystitis.
• More severe compilcations: empyema, perforation fistulas (from other organs there), inflamm of the biliary tree, obs cholestasis and pancreatitis
• Increased risk GB carcinoma

Question 6

cystic fibrosis

Answer 6

–>Formation of pancreatic intraductal concretions leads to duct obsts, low grade chronic autodigestion of pancreas, exocrine pancreatic insufficiency

Question 7

primary sclerosing cholangitis

Answer 7

IBD, cholangiocsarcoma

Question 8

full blown pancreatitis

Answer 8

• systemic inflamm leukocytosis, DIC, edema, ARDS (shock and acute renal tubular necrosis may occur)
• Peripheral vascular collapse.
• panc abcess, pseudocyst

Question 9

campylobacter enterocolitis

Answer 9

erythema nodosum

-guillianbarre synd: ascending paralysis

Question 10

gastric adenoma

Answer 10

FAP and chronic gastritis

Question 11

esophageal mucaosal webs

Answer 11

• GERD, chronic GVH dis, or blistering skin dis’s
• IF in upper esoph and have Fe-deficiency anemia, glossitis (smooth red inflamm. Of the tongue), koilonchia (spoon-shaped fingernail)and cheilosis (corners of mouth are cracked), may be indicative of Paterson-Brown-Kelly or Plummer-Vinson synd

Question 12

hepatoblastoma

Answer 12

FAP, Beckwith-Wiedemann synd. (WT2 gene abn)

Question 13

obliterative portal venopathy

Answer 13

rheumatologic dis

Question 14

nodular regenerative hyperplasia –> nodules

Answer 14

HIV, AI, portal HTN

Question 15

panc carcinoma

Answer 15

incave spleen, adrenals, colon, stomach, LNs, liver,lungs

Question 16

Lymphocytic (varioliform) Gastritis

Answer 16

-celiac

Question 17

hemochromatosis

Answer 17

o	Micronodular cirrhosis.
o	DM 
o	Abnormal skin pigmentation
o	Cardiac dysf
--hepatocellular carcinoma

Question 18

primary biliary cirrhosis

Answer 18

hypercholesteremia, and other AIs

Question 19

salmonella enteritica (typhoid fever)

Answer 19

gall stones and the chronic carrier state

Question 20

α1-antitrypsin deficiency

Answer 20

emphysema and hepatic dis, HCC

Question 21

carcinoid tumor

Answer 21

endocrine cell hyperplasia, AI chronic atrophic gastritis, MEN-1, and ZE synd

Question 22

juvenille polyps

Answer 22

intussusception, intestinal obstruction, or polyp prolapse, colonic adenocarcinoma

Question 23

nonalch fatty liver dis

Answer 23

metabolic synd (w obesity), hepatocellular carcinoma
-contrib ot progression of other liver dis's (HBV, HCV)

Question 24

esophageal varices

Answer 24

• alch cirrhosis

- schistosomiasis

Question 25

hepatic venous outflow obstruction (budd-chiari synd)

Answer 25

meloproliferative disorders such as polycythemia vera, inherited disorders of coagulation, antiphospholipid antibody syndrome, paroxysmal nocturnal hemoglobinuria, HCC

Question 26

acute appendicitis

Answer 26

- acute gangrenous appendicitis followed by perforation (suppurative peritonitis) - pyelophlebitis, portal v. Thrombosis, liver abscess, bacteremia

Question 27

carcinoid tumor of appendix

Answer 27

- Mucocele – dilated appendix filled w mucin - -Represent and obstructed appendix or may be a consequence of mucinous cystadenoma or mucinous cystadenocarcinoma (which wld spread) -Pseudomyxoma peritonei – when the abdomen fills w tenacious, semisolie mucin

Question 28

granulomatous gastritis

Answer 28

Crohn’s, sarcoid and infection (mycobacteria, fungi, CMV, H. Pylori).

Question 29

salmonella enteritidis (salmonellosis)

Answer 29

Severe illness more likely in pts with malignancy, immunosuppression, alcoholism, CV dysfunction, sickle cell disease, hemolytic anemia

Question 30

HSV

Answer 30

Acute herpetic gingivostomatitis, recurrent herpetic somatitis

Question 31

chronic pancreatitis

Answer 31

- panc indussifiency - DM - malabs - pseudocyst - panc canc

Question 32

Eosinophilic esophagitis

Answer 32

atopic dermatitis, allergic rhinitis, asthma, peripheral eosinophilia

Question 33

Ménétrier disease

Answer 33

gastric adenocarcinoma

Question 34

pigment stones

Answer 34

hemo anemias, severe ileal dysf or bypass, bac contamination of biliary tree

Question 35

celiac dis

Answer 35

- dermatitis herpetiformis | - t cell lymphoma (EATL) or small intestinal adenocarcinoma

Question 36

Zollinger-Ellison syndrome

Answer 36

MEN1 (Werner synd)

Question 37

apthous ulcer (canker sore)

Answer 37

sprue, Celiac’s, inflamm bowel disease, behcet's disease

Question 38

shigella

Answer 38

- Sterile reactive arthritis, urethritis, conjunctivitis in HLA-B27 (+) males 20-40 yo. - Serotype 1 leads to toxin causing hemolytic uremic syndrome

Question 39

GI stromal tumor in children

Answer 39

paraganglioma, pulmonary chrondroma (carney triad)

Question 40

peridontitis

Answer 40

systemic dis: infective endocarditis, brain abscesses, DS, AIDS, leukemia, Chrons, diab, sarcoidosis, syndromes assoc w neutrophil defect

Question 41

colonic adenocarcinoma

Answer 41

metastasis to liver, LNs, lung, bone

Question 42

Fundic gland polyp

Answer 42

FAP mutation

Question 43

AI gastritis

Answer 43

- vit B12 deficiency - atrophic glossitis - megaloblastic anemia (sometimes pernicious anemia) - diarrhea

Question 44

pyloric stenosis

Answer 44

turners synd, tri18 (edwards synd), erythromycin/azithromycin exposure in the first 2 weeks of life

Question 45

chrons dis

Answer 45

- Extraintestinal: migratory polyarthritis, sacroilitis, ankylosing spondylitis, erythema nodosum, uveitis, cholangitis, amyloidosis, finger clubbing. (same in UC too) - Increased risk of adenocarcinoma in pts with longstanding colon involvement. - Can lead to obst from strictures

Question 46

Familial adenomatous polyposis

Answer 46

- colorectal adenocarcinoma - neoplasia to ampulla of vater, stomach - gardner and turcot syndromes

Question 47

EHEC, O157:H7 type

Answer 47

HUS, ischemic colitis

Question 48

Hereditary Nonpolyposis Colorectal CAncer (lynch synd)

Answer 48

clusters CA at diff sites thru body