Autacoids

Question 1

Name the uricosuric drugs.

Answer 1

1. Probenecid
2. Sulfinpyrazone
3. Losartan
4. Fenofibrate
5. Lesinurad
6. Benzbromarone (effective in renal failure)

Question 2

Drugs used in acute gout.

Answer 2

1. NSAIDS— Indimethacin (DOC), Naproxen, Piroxicam, Diclofenac, Etoricoxib
2. Colchicine ( Inhibits release of chemotavtic factors and migration of leukocytes to the inflammed joints)
3. Corticosteroids- If only 1-2 joints are involved, intraarticular Triamcenolone can be given. Systemic steroids (Prednisone) given only when patient cannot tolerate NSAIDs/Colchicine or they are contraindicated (renal failure or peptic ulcer)

Question 3

Treatment of Status asthmaticus.

Answer 3

1. 100 mg i.v. Hydrocortisone given immediately.
   Followed by 100-200 mg i.v. infusion over 4-8 hours.
2. Nebulized Salbutamol (5mg) + Ipratropium bromide (0.5mg) - inhalational route
3. High flow oxygen inhalational
4. Salbutamol/Terbutaline i.m. or s.c. because inhalational drug may not reach peripheral bronchi adequately due to plugging of airways by mucus.
5. Intubation+ mechanical ventilation
6. Treat chest infection with intensive antibiotic therapy
7. Correct acidosis by Sod bicarbonate

7.