Autoimmune disorders

Question 1

What type of hypersensitivity reaction is SLE?

Answer 1

Type II ( Ab VS host damage multiple cells )
Type III ( Ag/Ab complex that deposits int tissue

Question 2

What is the common cause of death in SLE patients?

Answer 2

• 1. Renal failure

- 2. Infection

Question 3

What is the most common renal injury in SLE?

Answer 3

diffuse proliferative glomerulonephritis

Question 4

SLE is positive to what types of antibodies?

Answer 4

ANA and AntidsDNA

Question 5

What drugs can induce SLE?

Answer 5

Hydralazine, Procainamide, Isonizide

Question 6

drug- induced SLE is positive to what types of antibodies?

Answer 6

Antihistones antibody

Question 7

Antiphospholipid syndrome is positive to what types of antibodies? And what are their functions

Answer 7

• Anticardiolipin: Leads to false positive syphilis

- lupus anticoagulant: Falsely elevated PTT lab studies

Question 8

What is the complication of the lupus anticoagulant?

Answer 8

• Hypercoagulable state – results in arterial and venous thrombosis
• **Budd Chiari syndrome, placental thrombosis, etc

Question 9

What type of hypersensitivity reaction is the Sjogren Syndrome?

Answer 9

Type IV( lymphocyte mediate damage with fibrosis

Question 10

In Sjogren Syndrome what is the target of anti-SS A and anti-SS B?

Answer 10

Ribonucleoprotein

Question 11

Sjogren Syndrome is positive to what types of antibodies?

Answer 11

ANA and antiribonucleoprotein antibodies

Question 12

The Libman- Sacks endocarditis is seen in what pathology?

Answer 12

SLE

***Vegetations in both sides of the valve

Question 13

Patient with Sjogren Syndrome has a bilateral enlargement of the parotid gland. He consults becuase he sees that one is growin more thant the other one? Principle DX

Answer 13

B cell lymphoma

Question 14

What is scleroderma?

Answer 14

Autoimmune tissue damage with activation of fibroblast and deposition of collagen (fibrosis)

Question 15

Types of scleroderma

Answer 15

• Diffuse Type (skin and visceral involvement)

- Localized Type ( local skin and late visceral involvement)

Question 16

Patient consults for dysphagia of solids and liquids. You diagnose Sclerdoerma. Whta labs do you ask for to confirm the diagnosis?

Answer 16

Diffuse type of scleroderma

Ana and anti DNA topoisomerase I (Scl-70) antibody

Question 17

CREST

Answer 17

Calcinosis / anti Centromere antibodies
Raynaud phenomenon 
Esophageal Dysmotility 
Sclerodactily
Telangiectasis of skin

Question 18

Definition of Mixed connective tissue diseas and whta antibody is found in this disease?

Answer 18

Autoimmune mediate tissue damage with mixed features of SLE, systemic sclerosis, and POLYMYOSITIS
-U1 Ribonucleoprotein antibody