Barbituates

Question 1

MOA of barbituates

Answer 1

bind to barbituate binding site on GABA-A receptors

at high doses can act at GABA site

Question 2

CNS effects

Answer 2

reduce anxiety and hypnotic property

hard to separate, unlike benzodiazepines

Question 3

Pharmacokinetics of barbituates

Answer 3

strongly induce P450

Question 4

Barbituate intoxication

Answer 4

narrow therapeutic index

Question 5

Dependence on barbituates

Answer 5

physical dependence can be a serious problem. Tolerance develops to sedative-hypnotic effects, but not toxic effects