How does SNS and RAAS maintain BP?
SNS detects decreased CO and stimulates SNS which vasoconstricts. RAAS secretes renin, which converts angiotensin 1 to 2, which vasoconstricts. Also secretes aldosterone which retains water and sodium
S/s of compensatory stages of shock
Tachycardia, respiratory alkalosis, increased work of breathing, normal PaO2, blood pressure maintained, anxiety, pale, cool skin, oliguria
Progressive Shock
Hypotension, worsening tachycardia, worsening tachypnea, worsening oliguria, metabolic acidosis, decrease PaO2, clammy mottled skin, further changes in level of consciousness
Refractory Shock
Not responsive to interventions, MODS
Hypovolemic Shock and its Treatment
Reduction in intravascular volume leading to low tissue perfusion. Caused by third spacing or outside cause like burns, or bleed. Causes Narrow BP!!
SVR IS THE ONLY THING INCREASED FOR THIS SHOCK
-2 LARGE IV
-REPLACE VOLUME
-AVOID PRESSORS IF YOU CAN
-IDENTIFY CAUSE
-USE ISOTONIC FLUIDS
-USE FLUID WARMER IF OVER 2L OF FLUIDS BEING GIVEN IN 1 HR
NS vs LR
NS: LARGE VOLUMES MAY LEAD TO HYPERCHLOREMIC ACIDOSIS
DONT GIVE TO THOSE WITH HYPERNATREMIA AND RENAL FAILURE
LR: MIMICS ECF, MAY CAUSE LACTIC ACIDOSIS
Hemorrhagic Shock and its treatment. Risks of blood product
CLASSES 1- UP TO 750 ML/15%-CRYSTALLOIDS
2-UP TO 750-1500/15-30%-CRYSTALLOIDS
3 UP TO 1500-2000, 30-40%-CRYSTALLOID AND BLOOD
4 OVER 2000/OVER 40%-CRYSTALLOID AND BLOOD
STOP THE BLEEDING
RBC DON’T HAVE COAGULATION FACTORS SO CRYO (FIBRINOGEN), PLTS, AND FFP (INR)
-Trali, hypothermia, hypocalcemia, hypomagnesemia
Triad of death
HYPOTHERMIA, ACIDOSIS, COAGULOPATHY
MTP
10 units in 24 hrs or 5 units in less than 3 hours
SIRS
FEVER OR HYPOTHERMIA
HR OVER 90
RR OVER. 20 AND. UNDER 10
WBC HIGH OR LOW OR NORMAL
NO INFECTIOUS SOURCE
WHAT IS qSOFA score?
Bedside evaluation score to identify patients with suspected organ dysfunction:
1. Systolic 100 or lower?
2. RR equal or over 22
3. GCS under 15
2 or 3 score means high probability
Severe Sepsis
Sepsis and markers of organ dysfunction
Septic shock
Hypotension d/t infection
-pressors required despite adequate fluid resuscitation
-serum lactate over 2 despite fluid resuscitation
S/s of early septic shock and s/s of late septic shock
Early: tachy, hypo, but responds to pressors, lactate over 2, confusion, oliguria, fever
Late:hypotension, but not as responsive to pressors, lactate over 4, tachy, lethargy/coma, anuria, hypothermia
True or False: pt with sepsis or septic shock always has positive bc
FALSE
Treatment for septic shock/sepsis
-30ml/kg of CRYSTALLOID,
-if fluid not fixing bp, then start pressors-LEVO is first line, epi second
Add on vasopressin if already on large amount of pressors
-obtain bc as early as possible
-Abx after bc if possible within 1 to 3 hrs
-obtain lactate
-If MAP below 65 OR lactate is below 4, reassess the fluid status: ask provider or measure the cvp/assess fluid responsiveness with leg raise/bedside echo/measure scvo2
-Add on inotropic gut-dopamine
If oxygenation goals not met: consider more fluids, dobutamine get max 20, maybe PRBC if hub less than 7
End Goal of Septic Shock
-map adove 65
-decreased lactate
-normal hr
Normal uo
Warm extremities
Mentation is back
Source control
Oxygen goals met
Anaphylactic shock and its treatment
IgE mediated hypersensitivity reaction to protein substances such as penicillin, contrast media, bee sting, food, latex
Causes histamine release
Causes hypotension, decreased co, dilates, increases capillary permeability, and cause bronchospams, and laryngeal edema
Treatment include oxygen, remove offensive agent, and IM .3-.5 mg of epi, aggressive fluid, Benadryl, steroids give asap, inhaled beta adrenegric agent
Sequential Organ Failure Assessment (SOFA)
SCORE 0-4
HYPOTENSION
GCS
PAO2/FIO2
CREATININE OR UO
BILIRUBIN
PLATELET
HIGHEST 24, HIGHER WORSE
TRAUMA
ABCDEFG
AIRWAY
BREATHING
CIRCULATION
DISABILITY
FULL SET OF VITAL
SEDATION LEVELS
MINIMAL-REPSONDS TO VERBAL COMMANDS
MODERATE-REPSONDS TO VERBAL/TACTILE CAN MAINTAIN AIRWAY
DEEP-NOT EASILY AROUSABLE
GENERAL ANESTHESIA- LOSS OF CONSCIOUSNESS
AGITATION AND SEDATION WHAT TO RULE OUT
RULE OUT HYPOXEMIA, HEMODYNAMIC INSTABILITY, AND PAIN
-DELIRIUM, WITHDRAWAL, SLEEP DEPRIVATION, IMMOBILITY, ANESTHETICS, SEDATIVES, STEROIDS, PRE EXISTING CONDITIONS, DEMENTIA, ENVIRONMENTAL
PRECEDEX
-DO NOT PARALYZE SOMEONE ON DEX
-NO LOADING DOSE
KETAMINE
IV BOLUS AND GTT
MAY CAUSE HYPERSALIVATION/INCREASE IN BP/HR
-CAN CAUSE PSYCHOSIS/PRETREAT WITH A BENZO