Physics
Flow pressure (Paw) = Flow x resistance + Volume / compliance + baseline pressure (PEEP)
Only possible to change 2 out of 3:
Pressure
Flow
Volume
The other becomes dependent variable
Flow = volume / time
Main determinants
Inspiratory time
Respiratory Compilations
Ventilation Associated Lung Injury
Gas trapping
cardiovascular effect
NIV supplies positive pressure, causing reduced LV transmural pressure, leading to reduced after load
Hypotension
Drug induced
Gas trapping
Tension pneumothorax