Benzodiazepines

Question 1

what is the mechanism of action of benzodiazepines?

Answer 1

enhance the effector of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by increasing the frequency of chloride channels

Question 2

how long should benzodiazepines be prescribed for?

Answer 2

2-4 weeks

Question 3

how should a patient be withdrawn from a benzodiazepine?

Answer 3

1/8th of the daily dose every fortnight

Question 4

what are the features of benzodiazepine withdrawal syndrome?

Answer 4

• insomnia
• irritability
• anxiety
• tremor
• loss of appetite
• tinnitus
• perspiration
• perceptual disturbances
• seizure

Question 5

frequently bend - during barbeque

Answer 5

increase frequency of chloride channels = benzodiazepine

increase duration of chloride channels = barbiturates