Beta Oxidation

Question 1

Steg 1

Answer 1

Reaktion med HS-CoA:
Fettsyra + CoA ⟶ Acyl-CoA + H-S-Co

Question 2

Steg 2

Answer 2

Reaktion med FAD:
Acyl-CoA + FAD ⟶ Trans-Delta²-enoyl-CoA + FADH₂

Question 3

Steg 3

Answer 3

Väte elimineras:
Trans-Delta²-enoyl-CoA ⟶ L-3-Hydroxyacyl-CoA

Question 4

Steg 4

Answer 4

Dubbelbindning Cα=Cβ bildas:
L-3-Hydroxyacyl-CoA ⟶ 3-Ketoacyl-CoA

Question 5

Steg 5

Answer 5

H₂O adderas till dubbelbindningen:
3-Ketoacyl-CoA + H₂O ⟶ Acyl-CoA + Acetyl-CoA

Question 6

Återställning steg 1

Answer 6

Sekundär alkohol bildas:
Acyl-CoA + NAD⁺ ⟶ L-3-Hydroxyacyl-CoA + NADH + H⁺

Question 7

Återställning steg 2

Answer 7

NAD⁺ oxiderar alkoholen till keton:
L-3-Hydroxyacyl-CoA ⟶ 3-Ketoacyl-CoA

Question 8

Återställning steg 3

Answer 8

Acetyl-CoA spjälkas av:
3-Ketoacyl-CoA ⟶ Acyl-CoA + Acetyl-CoA