What is stored in the gallbladder?
Bile
Made in the liver, and stored and concentrated in Gallbladder.
Due to becoming more concentrated in the Gallbladder there is higher chance of precipitation and formation of gallstones.
What are the endocrine functions of the pancreas?
What are the exocrine functions of the pancreas?
Amylase: carbohydrate digestion
Trypsin: Protein digestion
Lipase: fat digestion
Secretin: bicarb secretion
What is another word for Cholelithiasis
gall stones
What are Cholelithiasis?
Stones formed in the gallbladder from the solid constituents of bile; they vary greatly in size, shape, and composition.
Two forms :
Pigment stones - cannot be dissolved and require surgery
Cholesterol stones - Its solubility depends on bile acids and lecithin (phospholipids) in bile
What genetic disease increases the risk of developing gallstones?
(Chart 44-1: Risk Factors – Cholelithiasis)
Cystic fibrosis
What metabolic disorder increases the risk of gallstones?
(Chart 44-1: Risk Factors – Cholelithiasis)
Diabetes
True / False
Frequent fluctuations in weight can increase the risk of gallstone formation.
True
What gastrointestinal condition increases gallstone risk due to impaired bile salt absorption?
(Chart 44-1: Risk Factors – Cholelithiasis)
Ileal disease or ileal resection
True / False
High and low-dose estrogen therapy affect gallstone risk
True - increases risk
What body composition factor increases the risk of cholelithiasis?
(Chart 44-1: Risk Factors – Cholelithiasis)
Obesity
Which demographic groups have a higher risk of developing gallstones?
(Chart 44-1: Risk Factors – Cholelithiasis)
Women
Women with multiple pregnancies
Native American populations
U.S. Southwestern Hispanic populations
What are the clinical manifestations of Cholelithiasis
Why may patients with Gallstones develop jaundice?
Due to possible obstruction of the common bile duct. Bilirubin cannot drain into the GI for excretion.
What studies visualize the gallbladder and bile ducts?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
These imaging studies visualize the gallbladder and bile ducts.
What diagnostic procedure allows visualization of the liver, gallbladder, and mesentery using a trocar?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Allows direct visualization of the anterior surface of the liver, gallbladder, and mesentery
What imaging study is commonly used to evaluate abdominal organ size and detect masses?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Shows organ size
Detects masses or gallstones
What imaging studies detect tumors, cysts, pseudocysts, abscesses, hematomas, and assess severity of pancreatitis?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Used to:
Detect neoplasms
Diagnose cysts, pseudocysts, abscesses, hematomas
Determine severity of pancreatitis
What diagnostic test visualizes biliary structures and the pancreas through endoscopy?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Combines endoscopy and fluoroscopy
Visualizes biliary ducts and pancreas
What lab test is used to detect biliary tract obstruction when bone disease is absent?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Elevated levels suggest biliary obstruction
What laboratory markers indicate biliary stasis and may also be elevated in alcohol abuse?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Gamma-glutamyl transferase (GGT)
Gamma-glutamyl transpeptidase
Lactate dehydrogenase (LDH)
How do cholesterol levels change in biliary obstruction and liver disease?
(TABLE 44-1: Studies Used in the Diagnosis of Biliary Tract and Pancreatic Disease)
Elevated cholesterol → biliary obstruction
Decreased cholesterol → parenchymal liver disease
Is the following statement true or false?
Cholecystitis is when a patient has calculi in the gallbladder.
False
Rationale: Cholecystitis is inflammation of the gallbladder. Cholelithiasis is when a patient has calculi in the gallbladder
What are the medical managements of cholelithiasis?
Laparoscopic cholecystectomy - surgically removal of gallbladder