Biliary Secretion

Question 1

functions of the liver

Answer 1

• bile production and secretion
• metabolism of carbs, proteins, lipids
• bilirubin production and excretion
• detoxification of substances

Question 2

metabolic functions of the liver: carbs

Answer 2

glucose storage as glycogen
gluconeogenesis
release of glucose

Question 3

metabolic functions of liver: proteins

Answer 3

• albumin and clotting factors (liver failure leads to hypoalbuminemia which may lead to edema)
• synthesis of nonessential amino acids
• modication of amino acids for use in biosyn pathways for carbs
• conversion of ammonia to urea

Question 4

metabolic functions of liver: lipids

Answer 4

• fatty acid oxidation

- synthesis of lipoproteins, cholesterol, phospholipids

Question 5

what makes up bile?

Answer 5

bile salts 50%
phospholipids 40% (lecithin)
cholesterol 4 % 
bile pigments (billirubin) 2 %
ions
H2O

Question 6

primary bile acids and which one is the most soluble

Answer 6

cholic acid and chenodeoxycholic acid

cholic acid is most soluble bc it has the most OH groups on it

Question 7

secondary bile acids and least soluble

Answer 7

deoxycholic acid and lithocholic acid

lithocholic acid is least soluble

Question 8

what are bile acids conjugated with and what is the reason

Answer 8

conjugated with taurine and glycine to make them more water soluble

Question 9

predominant cation and anions in bile

Answer 9

Na+

Cl- and HCO3-