STR
Single tandem repeat. Helps differentiate between people’s DNA.
(TTTTTT vs TTTTTTTTTTTTTT)
Homology
Similar traits that come from common ancestor
Analogy
Similar traits that develop separately
Proto-oncogene
regulate cell growth. gene that if TURNED ON leads to cancer
Tumor suppressor genes
regulate cell growth, brakes on cell growth that leads to cancer. genes that if TURNED OFF leads to cancer
Telomere
shortens with each DNA synthesis, causing aging. if telomerase is TURNED ON in non-gonadal cells it leads to cancer
Contact Inhibition
Cells cease growth if they touch each other. if TURNED OFF causes cancer
Anchorage Dependence
requires normal cells to attatch to a solid surface tospread and grow, if TURNED OFF causes cancer
Chargaff’s Rule
Equal # of A & T. Also G & C
Law of Segregation
each gametes contains only a single allele of any given gene
Law of Independent Assortment
alleles of different genes should be passed on independent of each other
Linked Genes
Exceptions to Law of Independent Assortment. Genes close to each other on chromosome often get inherited together
Helicase
“unzips” 2 strands of DNA by breaking H bonds
DNA Polymerase
“builder”, replicates DNA molecules to build new strand of DNA
Primase
“initializer”, makes primers so DNA Polymerase can figure out where to start
Ligase
“glues” DNA fragments together
PCR
method used to make a ton of copies of a specific DNA sample
qPCR
monitors amplification of targeted DNA molecules during PCR. Measures in increases in florescent signals
Western Blot
detects specific PROTEINS in sample by creating antibodies that bind to the protein and show up on the test
Northern Blot
study gene expression by detection of RNA in sample. can see if something’s off in patients by unusual amounts of RNA
Nondisjunction
happens in Anaphase. Chromosomes/chromatids separate unequally
incomplete dominance
dominant and recessive, but dominant cant take over completely. creates new phenotype (ex: red + white= pink)
Codominance
2 dominant. both take up dominance. (ex: spotted pink and white flower)
Ploidy Number
number of copies of chromosomes (2n, 3n, etc.)