Who discovered the structure of DNA?
James Watson and Francis Crick
Who was the woman who helped the 2 men discover the structure of DNA and how?
Rosalind Franklin, she took Photo 51
What is the small chunk of the DNA called?
Nucleotide
What is a nucleotide made of- draw it?
Phosphate, sugar, nitrogen containing base
What are the different stages of protein synthesis?
Transcription and translation
Where do the different stages of protein synthesis take place?
Transcription in the nucleus. Translation in a ribosome.
What happens in the first stage of protein synthesis?
In transcription, the DNA unzips, the mRNA matches bases with the DNA to copy the instructions and then the mRNA leaves the nucleus to find a ribosome for the next stage.
What happens in the second stage of protein synthesis?
After finding a ribosome the mRNA enters it and translation takes place. In translation the ribosome translates the codons into Amino Acids (creating them)
What is a mutation?
It is a change in the DNA sequence
What are the 2 different types of mutations and what do they do?
Substitution where one base is substituted/changed. Frameshift where one base is deleted or one base is added
What are the different things that can happen in a substitution mutation
Missense- where the Amino Acid is changed
Silent- where the Amino Acid isn’t changed
Nonsense- when an early STOP is caused
What are the different things that can happen in frameshift mutation?
No matter what all of the Amino Acids down the line after the frameshift will be changed.
- Insertion- When a base is added (extra letter)
- Deletion- When a base is deleted (missing letter)
What is a codon?
Pair of 3 letters
What is heterozygous and homozygous?
Heterozygous is when they are different letters and homozygous is when they are both the same letter
What is a phenotype and what is a genotype
The phenotype is the physical appearance of the trait and the genotype is the letters that code for it
What are the different Non Mendelian genetics
What is a pedigree?
It is a tool used to study inherited diseases. It helps to show the risk of disease in future generations.
In a pedigree what does a circle represent?
Female
In a pedigree what does a square represent?
Male
In a pedigree what does shaded mean?
They are infected with the disease
What does autosomal mean?
Autosomal means the disease is not linked to the sex of an individual.
What does X-linked mean?
X-linked means the disease is linked to the sex of an individual
What does recessive mean in a pedigree?
It means the disease is linked to a recessive gene (is a recessive gene)
What does dominant mean in a pedigree?
It means the disease is linked to a dominant gene (is a dominant gene)