1
Q
Define bioavailability
A
The fraction of the dose administered that reaches the systemic circulation in its active form
2
Q
The extent of first pass metabolism is more important for high or low hepatic extraction ratio drugs?
A
High
3
Q
Name some factors that might reduce the bioavailability of an IV administrated drug
A
- adsorption to equipment
- missing vein or artery
- drug interaction in IV bag
4
Q
Absolute bioavailability =?
A
Oral bioavailability / IV bioavailability
5
Q
If the hepatic extraction ratio (Eh) is 0.75, what is the Fh?
A
0.25
6
Q
Fg?
A
Fraction of dose that is absorbed from gut
7
Q
Is bioavailability dependent on the dose?
A
No
