What are the physicochemical factors influencing bioavailability?
Dissolution, solubility, crystal form, and salt formation
What factors can affect the concentration of a drug in solution in the gastrointestinal fluids
complexation, adorption, and chemical stability of the drug in the gastrointestinal fluids
Are solvates more soluble than solutes or less?
More soluble due to water being more present in the coumpound
Adsorption
when a drug binding to the surface of the gut wall lowers the concentration of the overall drug, affecting bioavailability
Drug absorption
drug dissociation and lipid solubility
What promotes better absorption
having more hydrogen bonds
How does dosage affect bioavailability
Solubilization
the incorporation of the drug into micelles to increase its aqueous solubility
How does the viscosity of a solution dosage form affect solubility?
it lowers it
Do micelles lead to better or worse bioavailibility?
Better
Aqueous suspension
particle size is important so that if more surface area is shown, bioavailability is better
how to keep suspending agents suspended?
Higher vsscosity and overcome surface tension between the identical particles
Powder-filled capsules
What does it mean the salt form of a weak acid or aweak base
What can happen between the interaction of the capsule shell and its contents?
Uncoated tablets
