bioavailability

Question 1

Bioavailability

Answer 1

• Indicates the fractional extent to which a dose of drug reaches the site of action.
• Depends on dissolution and absorption
• For the oral route of administration, bioavailability can be altered by stability in gastric fluids, formulation components, and the hepatic first-pass effect.

Question 2

• Three indices of bioavailability

Answer 2

• Three indices of bioavailability include:
 Cmax
 tmax  AUC

Question 3

Bioequivalence

Answer 3

• Used to describe the bioavailability of a drug in two different formulations.
• Important for comparing generic products with the brand name (innovator) product.
Testing typically involves in vivo human PK studies to evaluate the rate and extent of absorption.