Inflammation v. Neoplasia on cytology?
Inflammation- has inflam. cells (neutrophils, macrophage,eosinophil)
Neoplasia: no sig inflammation seen and 1 cell type found
Goal of excisional biopsy
Remove the whole lesion, with the goal of dx & tx
- done with small lesions & when have low degree of malignancy
Goal of incisional Biopsy
Dx only
Done with wedge, true cut or punch biopsy
Incisional biopsy should be used with superficial lesions? T/F
True, lesion should be less than 1 cm
cutaneous or intra-cavitary
What is guillotine biopsy used in?
Tip of organs (liver, pancreas, lung, LN)
- loop around area & have constant tension
Should you use a wedge biopsy technique with tumors?
No, although the biopsy is large/representative, you can transfer tumor cells to normal areas
Pro/Con: punch biopsy
P: cut easy and good for superficial lesion
C: small sample, may not reach deep sample
- ideal for small dermatologic lesions/ liver
Pro/Con: tru cut biopsy
P: good for deep lesions (us/ct guided)
C: small samples, hemorrhage (sx repair)
Pro/Con: Guillotine biopsy
P: simple & remove large sample on tip (liver)
C: lesions need to be on the tip
Pro/Con: wedge biopsy
P: large samples
C: more sx exp. & suture for hemorrhage
When do you use a bone biopsy?
Pro/con
When large needle cytology fails to dx sarcoma or osteomyelitis
- pro: large sample
- con: requires GA & risk of iatrogenic fx
Where do most bone tumors originate from?
Endosteum, so sample cannot be superficial
Its okay to take sample from center of a large soft tissue mass?
False, tumors receive blood from skin & muscle surround so has necrotic center
Blood supply for bone vs soft tissue
Bone- central blood supply
ST- peripheral blood supply
What is the landmark used for nasal biopsy?
Medial canthus, beyond is cribiform plate & get brain biopsy
Recommended margins for mct and soft tissue sarcoma (k9)?
3 cm margin and 1 fascial plane deep
Feline injection site sarcoma margins
5 cm margins and 2 fascial planes
How can you control post biopsy bleeding?
Acepromazine, icing nose, neosynephrin(afrin), yunan baiao & umbilical tapen
