Bisphosphonate

Question 1

Stabilizes hydroxyapatite structure
Induce osteoblast to secrete inhibitors of osteoclast

Slows progress of osteoporosis

Answer 1

Bisphosphonate
Alendronate
Etidronate
Pamidronate
Risedronate

Question 2

Peptide hormone by thyroid gland

Decreases bone resorption
Decreases serum calcium and phosphate

Answer 2

Paget’s disease

Hypercalcemia

Question 3

Osteitis deformans pathologic fracture

Answer 3

Mosaic lamellar bone pattern

Question 4

Etidronate and pamidronate SE

Answer 4

Bone mineralization defect (lose effectiveness after 12 months)
GI distress including esophageal ulcers (aledronate)

Question 5

Drug for OCP induced osteoporosis

Answer 5

Alendronate

Question 6

Osteoporosis type of fx

Answer 6

Subcapital

Question 7

Bisphosphonate indications

Answer 7

Paget disease
Postmenopausal osteoporosis
Alendronate is the DOC for steroid-induced osteoporosis