- Statins - Sodium Valproate - Methotrexate - Flucloxacillin - Carbamazepine - Sulfasalazine - Paracetamol - Doxycycline, Tetracycline, Lymecycline, Oxytet - Azathioprine, Mercaptopurine - Isoniazid - Fluconazole, Itraconazole

- NSAIDs - Bisphosphonates - Cephalosporins - Aciclovir - Ciclosporin - Gentamicin, Vancomycin - Trimethoprim - Tacrolimus, Penacillamine - Methotrexate

Bits to Know Flashcards by Carys Pritchard

Hepatotoxic Drugs

Statins
Sodium Valproate
Methotrexate
Flucloxacillin
Carbamazepine
Sulfasalazine
Paracetamol
Doxycycline, Tetracycline, Lymecycline, Oxytet
Azathioprine, Mercaptopurine
Isoniazid
Fluconazole, Itraconazole

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Nephrotoxic Drugs

NSAIDs
Bisphosphonates
Cephalosporins
Aciclovir
Ciclosporin
Gentamicin, Vancomycin
Trimethoprim
Tacrolimus, Penacillamine
Methotrexate

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Drugs with Anticoagulant Effects

Acenocouramol, Warfarin
DOACs
Heparin/LMWH
Clot Busters - alteplase, streptokinase, urokinase

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Drugs with Anti-platelet Effects

SSRI/SNRIs - Citalopram, Duloxetine, Escitalopram, Fluoxetine, Venlafaxine, Sertraline, Paroxetine
NSAIDs - Aspirin, Naproxen, Diclofenac
Antiplatelets - Clopidogrel, Prasugrel, Dipyridamole
Omega 3

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Drugs that cause Thromboembolism

Chemotherapy Drugs - fluorouracil, tamoxifen, methotrexate
Tranexamic Acid

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Drugs that cause Bradycardia

Βeta Blockers
Rate-Limiting CCBs - Verapamil/Diltiazem
Amiodarone, Digoxin
Opioids - alfentanil, fentanyl, methadone
Dementia Drugs - donepezil, galantamine
Parkinson’s Drugs - rivastigmine, selegiline

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Drugs that cause FIRST DOSE Hypotension

ACE
ARBs
Alpha Blockers
Tamsulosin (C/I in postural hypotension)
Nitrates - GTN + Isosorbide

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Drugs that cause hypotension

ACE, ARBs, Β Blockers, CCBs, Alpha Blockers, Diuretics
Nitrates
SGLT2
Phosphodiesterase - Sildenafil, Avanafil
Levodopa, Methyldopa
Antipsychotics (postural hypotension)
Tamsulosin
MOA Inhibitors

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Interactions - Drug Inducers

CRAP GPS

Carbamazepine
Rifampicin
Alcohol
Phenytoin
Griseofulvin
Phenobarbitone
St John’s Wart

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Interactions - Drug Inhibitors

SICKFACES.COM

Sodium Valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol + Grapfruite Juice
Chloramphenicol
Erythromycin/Clarithromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole

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Drugs that prolong the QT interval

Amiodarone, Sotalol
Citalopram, Escitalopram, Venlafaxine
Clarithromycin, Erythromycin
Lithium
Flecainide
Ondansetron
Quinine
Hydroxyzine
Antipsychotics
Fluconazole, Voriconazole
Methadone
Ranolazine
Tolterodine
Sildenafil

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Drugs with antimuscarinic effects

Inhaled Antimuscarinics (-ium)
Hydroxyzine
Hyoscine, Promethazine, Chlorphenamine
Cyclizine
Trospium, Oxybutynin, Solifenacin, Tolterodine
Procyclidine
Nortriptyline, Amitryptiline
Baclofen
Amantadine

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Drugs with CNS depressant effects

Alcohol
Opioids
TCAs
Benzos
Z Drugs, Melatonin
Mirtazapine
Antipsychotics
Baclofen
Cinnarizine, Clorphenamine, Cyclizine
AEDs - Levetiracetam, Lamotrigine

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Drugs that cause peripheral neuropathy

Amiodarone
Disulifram
Isoniazid
Metronidazole
Nitrofurantoin
Phenytoin

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Drugs that cause serotonin syndrome

SSRIs, SNRIs, Mirtazapine
MOA/B Inhibitors - Selegiline, Rasagiline
Triptans
Tramadol, Fentanyl, Methadone, Pethidine
Ondansetron
Amfetamines
Lithium
St John’s Wort

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Drugs that cause bone marrow suppression

Study These Flashcards

Sulfasalazine
Azathioprine/Mercaptopurine
Methotrexate
Immunoglobulins
Chemotherapy
All chemo except bleomycin + vinca

Drugs that cause HYPER kalaemia

Study These Flashcards

NSAIDs
ACE/ARBs
Trimethoprim
Tacrolimus
K Sparing Diuretics
Ciclosporin
LMWHs

Drugs that cause HYPO kalaemia

Study These Flashcards

Aminophylline/Theophylline
Diuretics (Furosemide, Indapamide, Thiazides)
Corticosteroids (Pred, Beclomethasone)
Β Agonists (Salbutamol, Formoterol)
Amphotericin B

Drugs that cause HYPO natraemia

Study These Flashcards

SSRI/SNRI
NSAIDs
All Diuretics
Amitriptyline, Nortriptyline
Carbamazepine
Desmopressin
Gabapentin

Drugs that cause ototoxicity

Study These Flashcards

Vancomycin, Gentamicin
Furosemide, Bumetanide (LOOPS)
Chemo - cisplatin, vincristine etc.

Drugs that are teratogenic/avoid in pregnancy

Study These Flashcards

Warfarin
Statins (discontinue 3 months before conceiving, protection during + 1 month after)
Colchicine
Exemestane
Finasteride (to male foetus), Dutasteride
Sodium Valproate
Methotrexate - 6 months after
Mycophenolate - 6 weeks/90 days after for women/men respectively
Aza/Mercaptopurine
Tacrolimus, Ciclosporin
Tretinoins
Ondansetron 1st Tri = cleft palate
ALL antihypertensives except Labetalol
ALL AEDs except lamotrigine + levetiracetam
Tetracyclines
Chloramphenicol
Vitamin A (Retinol)
Lithium
Oestrogens/Progestorens

Common Infections + Causative Organisms

Study These Flashcards

Otitis Media
- Strep pneumonia

Eyes

Staph aureus
Neisseria gonorrhoea
Chlamydia trachmoatis

CAP (Lower Infection)

Strep pneumoniae
Haemophilus influenza

Upper Resp Infection

Strep pyogenes
Haemophilus influenza

Sinusitis

Strep pneumonia
Haemophilus influenza

Skin

Staph aureus
Strep pyogenes

Gastritis

H pylori
C diff

Food Poisoning

Campylobacter jejune
Salmonella
E Coli

UTI
- E Coli

STI

Chlamydia
Neisseria gonorrhoea

Drugs to Withhold in AKI

Study These Flashcards

ACE/ARBs
Metformin
Diuretics
NSAIDs
Tramadol, Gabapentin, Pregabalin - renally cleared
Bisphosphonates, Lithium, Digoxin

Key Food/Drink-Drug Interactions

Study These Flashcards

Levothyroxine + Caffeine Drugs
Cranberry/Pomegranate, Green Veg + Warfarin
Grapefruit + Amlodipine, Statins
Bisphosphonates + Ca (Milk/Supplements)
MAOIs and Tyramine Foods
Theophylline, Clozapine, Olanzapine + Smoking
Theophylline + Caffiene
Ciprofloxacin, Tetracyclines + Dairy products
Metronidazole + Alcohol
Lithium + changes to salt
Ciclosporin + Grapefruit, Pomelo, Purple Grape
Tacrolimus + Grapefruit, Pomelo + Pomegranate
Amiodarone + Grapefruit

Drugs to be taken WITH/AFTER food

- Rivaroxaban - Mefloquine/Atovquone - Iron (should be empty stomach but GI effects) - Metformin - NSAIDs - Steroids - Allopurinol (N&V) - Metronidazole - Nitrofurantoin - Clarithromycin - Pivmecillinam

Drugs to avoid indigestion/antacid remedies ``` PPIs Tetracyclines Quinolones Bisphosphonates Levothyroxine ```

- PPIs - affects pH - Levothyroxine - separate by at least 4 hours - Doxycycline, Lymecycline - seperate by 2-3 hours - Bisphosphonates - binds to calcium - Ciprofloxacin, Levofloxacin (2 hours before/4 hours after) - Digoxin - separate by 2 hours - Fexofenadine - separate by 2 hours - Gabapentin - separate by 2 hours - Hydroxychloroquine/ Chloroquine - 4 horus - Iron - 1 hour before/2 hours after - Azoles - 2 hours before/1 hour after

Drugs most likely to cause Steven Johnson's Syndrome

- Allopurinol - Carbamazepine, Lamotrigine, Phenobarbital, Phenytoin - Sulfasalazine - Gentamicin - Sulfa Abx - Oxicam NSAIDs

Drugs that cause taste disturbances

- Metformin - Metronidazole - Chlorhexidine - Amoxicillin - Amiodarone - Calcitonin - Carbimazole - ACE inhibitors - Clarithromycin - Zopiclone - Lithium Salts - Terbinafine

Drugs to be taken ON AN EMPTY STOMACH

- PPIs - take 30 minute before food for pH control - Flucloxacillin + Pen V - Levothyroxine - Bisphosphonates (wait 30 mins after) - Azithromycin (Caps) - Tetracycline/Oxytetracycline

Drugs to avoid sunlight/exposure

- Doxycycline - Amiodarone - Quinolones - Isotretinoin - Tacrolimus - Ciclosporin

Drugs that cause dyspepsia

- Alpha Blockers - Antimuscarinics - Aspirin/NSAIDs - Β Blockers - Bisphosphonates - CCBs - Corticosteroids - Nitrates - Nicorandil - Theophylline - TCAs - Benzos

Drugs that cause intracranial hypertension?

- Amiodarone - Ciclosporin - Tetracyclines - Isotretinoin - Steroids - COC

Drugs that cause gingival hyperplasia

- Ciclosporin - CCBs - Phenytoin

Bits to Know Flashcards

(33 cards)