Main NT of the PNS
Ach- both pre and post ganglionic
COtransmiters of the PNS
ATP, peptides are also in Ach vesicles
Botulinum - MOA
cleaves certain VAMPs and SNAPs preventing Ach release
prevanglionic NT of SNS
Ach
SNS NT @ sweat glands
Ach on M
SNS NT @ cardiac and smooth muscle cells, glands, and nerve terminals
alpha and beta receptors
SNS NT @ renal vascular smooth muscle
D @ D1
NE precursor
Tyrosine
what are steps of NE synthesis
Tyrosine –> DOPA –> Dopamine –> NE –> Epi
enzyme that catalyzes tyrosine –> Dopa
tyrosine hydroxylase
inhibited by metryrosine
Mech of NE signal termination
terminated by reuptake or diffusion out of the synapse