Bone and Soft Tissue

Question 1

Brittle bone disease?

Answer 1

Osteogenesis Imperfecta

Question 2

1) Type 1 collagen?
2) type 2 collagen?
3) type 2 hypersensitivity?

Answer 2

1) Osteogenesis Imperfecta
2) osteoarthritis
3) myasthenia gravis

Question 3

Treatment of osteoporosis?

Answer 3

• Calcium and Vit D supplementation
• Weight bearing exercise
• Biphosphonates - decrease osteoclast-mediated bone resorption.

Question 4

defective dentin in Osteogenesis Imperfecta is called?

Answer 4

dentinogenesis imperfecta

Question 5

3 phases of development of Paget’s disease and fibrous dysplasia?

Answer 5

1) Osteoclastic: bone loss, hypervascularity
2) Osteoclastic and osteoblastic
3) Osteoblastic: formation of dense, mineralized bone

Question 6

Most of Paget’s are monostotic or polyostotic?

Answer 6

polyostotic

Question 7

1) 1 to 2.5 is?

2) below 1 is?

Answer 7

1) osteopenia

2) osteoporosis

Question 8

Osteomyelitis casued by what bacteria?

Answer 8

Actinomycosis

Question 9

New bone around dead bone is called?

Answer 9

involucrum

Question 10

DEG stands for?

Answer 10

Drugs, Endocrine (thyroid), Gastric malnutrition (Vit D)

*** osteoporosis!

Question 11

sequestra

Answer 11

dead bone

Question 12

Paget’s has elevated _____ and normal levels of?

Answer 12

elevated serum alkaline phosphatase due to increased osteoblastic activity
•Serum calcium and phosphate are normal

Question 13

What drugs inhibit osteoclast activity?

Answer 13

Prolia and bisphosphanate!

• osteoclast has RankL
• Osteoblast has RANK

Question 14

APC gene

Answer 14

Gardners Syndrome

Question 15

Osteogenesis Imperfecta

Answer 15

• autosomal dominant
• Brittle bone disease
• Blue sclera, dentinogenesis imperfecta, hearing loss

Question 16

Osteopetrosis

Answer 16

• reduced osteoClast activity
• defective REMODELING! Bone calcification ok
• bone densitity or radioopaque
• CN probs due to compression

Question 17

obliteration of bone marrow in osteopetrosis causes/

Answer 17

• Reduced hematopoiesis
• Recurrent infections
• Normocytic anemia

Question 18

Osteoporosis is caused by?

**Idiopathic or secondary to?

Answer 18

menapuasal woman!
**Idiopathic or secondary to corticosteroids or multiple
myeloma

Question 19

onion

Answer 19

chronic osteomyelitits (children) OR ewing sarcoma

Question 20

F > M

Answer 20

• giant cell tumor (brown’s tumor)
• osteoporosis
• myasthenia gravis
• fibrous dysplasia

Question 21

Ewings syndrome mimics?

Answer 21

osteomyelitis

Question 22

Paget’s Disease/ Osteitis

Deformans is associated with what bacteria?

Answer 22

paramyxovirus

Question 23

MuSK protein

Answer 23

myasthenia gravis

Question 24

fibrous dysplasia is commonly monostotic or polystotic?

Answer 24

monostotic

Question 25

11/22 or 21/22 translocation?

Answer 25

Ewings syndrome

Question 26

T or F mineral content is normal in osteoporosis?

Answer 26

True

Question 27

1) Osteoporosis characterized by increased? 2) common fractures? 3) fractures lead to?

Answer 27

1) porosity of the skeleton resulting from reduced bone mass 2) Spine and femoral neck are prone for fractures 3) Loss of height and kyphoscoliosis • Femoral neck fractures results in immobilization may lead to pulmonary embolism and pneumonia

Question 28

Chronic osteomyelitis affects?

Answer 28

children! usually apical to mandibular first molar teeth, osteoblastic type

Question 29

Paget’s Disease/ Osteitis | Deformans is characterized by frenzied?

Answer 29

osteoClastic activity followed by exuberant bone formation due to osteoblastic activity (he excess bone is architecturally abnormal and unstable)

Question 30

Codmans triangle

Answer 30

Osteosarcoma

Question 31

Eburnation

Answer 31

Smoothing of subchondral bone, polished | ** osteoarthritis

Question 32

Joint mice and osteophytes

Answer 32

Osteoarthritis

Question 33

Crepitus

Answer 33

Cracking sound of bones | ** osteoarthritis

Question 34

Heberden nodes

Answer 34

Osteoarthritis | Small osteophytes on distal

Question 35

GNAS gene

Answer 35

Fibrous dysplasia

Question 36

Pagets is secondary cause of?

Answer 36

Osteosarcoma