- Joe Bob showed up to school one day irritated after a recent round of vaccinations. To cheer him up one of his friends, Peggy Sue, gave him a peanut butter cookie. His lips became swollen and he had trouble breathing. Upon visiting your clinic, his parents ask you to test him for peanut allergies. A small blood sample is withdrawn and you measure:
D. Antigen-specific (peanut) IgE levels.
- The disease IPEX is caused by mutations in:
D. Foxp3 that is required for T reg development and maintenance.
- T regs function by all of the following mechanisms except:
D. Induction of receptor editing in extrathymic CD4 cells.
- What type I hypersensitivity reaction does not require antibodies?
B. Type IV.
- APECED is caused by mutations in:
Aire mutations that decrease negative selection.
- The destruction of beta cells causes which autoimmune disease:
D. Type I diabetes.
- Which of the following is a diagnostic for SLE?
anti-dsDNA antibodies.
- Epitope spreading refers to:
D. The broadening of the specificity of self responses during autoimmunity.
- Cancer cells must:
A. Become resistant to apoptosis to cause malignant tumors.
- Which of the following is promising strategy to augment anti-tumor immune responses?
B. Blocking inhibitory receptor-ligand interactions.
A. Blocking inhibitory receptor-ligand interactions.
B. Possess the same major and minor histocompatibility antigens.
- Direct allorecognition occurs when:
C. Host T cells recognize donor HLA on donor DCs
- Which of the following deficiencies hinders adaptive immunity directly:
C. X-linked agammaglobulinemia.
- Loss of which cell type precludes AIDS and death during HIV infection:
CD4+ T cells.
FK506 and cyclosporine function by:
Blocking NFAT nuclear translocation.
- Omalizumab is currently used to :
D. Treat chronic asthma.
