1
Q
Bornavirus disease in humans?
A
Borna Disease Virus
2
Q
genome?
A
Enveloped -ssRNA
3
Q
Pathogenesis
A
Neurotropic. spreads throughout CNS.
establishes persistent infection. T cell immune responses important but also cause damage.
4
Q
symptoms
A
limited understanding in humans. presence of antibodies to virus in patients with schizophrenia, autism, and other neurapsychiatric diseases. suggests BDV either causes or exacerbates.
5
Q
epidemiology
A
zoonosis in horses and sheep. no reservoir or mode of transmission known.
6
Q
Diagnosis
A
RT-PCR
serologic analysis of antibody to viral proteins
7
Q
Treatment
A
no vaccine, ribavirin.
