brain abscess

Question 1

considerations of antibiotic treatment

Answer 1

physiological properties of BBB and BCSF barrier are distinct. penetration of drugs into CSF and brain tissue differ

Question 2

which antibiotics are used

Answer 2

ampicillin, penicillin, cefuroxime, cefotaxime, ceftazidime, metronidazole –> therapeutic concentrations in intracranial pus

Question 3

sinugenic/ odontogenic abscess

Answer 3

cefotaxime 2g 6hrly

metronidazole 500mg 8hrly (both IV)

Question 4

otogenic abscess

Answer 4

benzyl penicillin 2.4g 6hrly
ceftazidime 2g 8hrly
metronidazole 500mg 8hrly (all IV)