Breast Malignancies

Question 1

2 Key Histo findings of the LOW Cancer Risk, Proliferative Lesion: Sclerosing Adenosis

Answer 1

1. Lots of Fibrosis & Matrix
2. Radial Scar Stroma

Question 2

Fibroadenomas and Phylloides tumors affect the _____ of the breast

Answer 2

Stroma

Question 3

What are 3 atypical presentations of breast cancer?

Answer 3

1. Eczematous Skin
2. Scaly Skin
3. Red Inflamm

Question 4

Atypical Breast Cancer from Paget’s results from Ductal infiltrate into the _______, whereas Inflamm Breast cancer has Ductal infiltrates into the _____

Answer 4

• Epidermis
• Lymph Nodes

Question 5

Key histo finding of Fibroadneoma?

Answer 5

Compressed Gland

(Look like slit)

Question 6

Intraductal papilloma, abscesses/mastitis, and paget’s disease all affect the ______ and _____ of the breast

Answer 6

• Lactiferous Duct
• Major Duct

Question 7

Ddx for breast lump in 20-year-old

Answer 7

Acute Mastitis (Lactational or Nonlactational infection)

Question 8

Key surface markers for breast cancer?

Answer 8

1. Estrogen
2. Progesterone
3. Her-2/Neu

Question 9

A phylloides tumor is similar to a fibroadenoma because it ALSO makes a stromal tumor, however, it is associated with chromosomal changes, and has high levels of ______ activity

Answer 9

Mitotic

Question 10

What risk do Papillomas, sclerosing adenosis, Fibroadenomas, and a Phylloides tumor have towards cancer?

Answer 10

Low-Risk

Question 11

Ddx for breast lump in 60-year-old

Answer 11

Cancer

Question 12

The breast Acini, just like the prostate are _____ cells thick

Answer 12

2

Question 13

BRCA1 and 2 are both ______ proteins

Answer 13

Anti-Tumor

Question 14

Key clinical finding of the Proliferative Intraductal Papilloma of the breast?

Answer 14

BLOODY NIPPLE

Question 15

Periductal Mastitis commonly occurs with people who _____

Answer 15

Smoke

Question 16

Paget disease malignant cells fail to have a _____ stain

Answer 16

Cytokeratin

Question 17

Key difference from Lobular vs Ductal carcinoma aside from the location?

Answer 17

Only DUCTAL is actually a true cancer

Question 18

Invasive lobular Carcinoma has what key histo finding?

Answer 18

Indian File-Cell Arrangement

Question 19

Acute mastitis, Periductal mastitis, Duct Ectasia all share what in common in regards to breast pathology?

Answer 19

Benign Breast Disease

Question 20

Simple Cysts, Fibrosis, Apocrine Metaplasia, and Adenosis all share what in common in regards to breast pathology?

Answer 20

Non-Proliferative Breast Changes

Question 21

Define Breast Adenosis and when it’s seen

Answer 21

• Increased acini per lobule
• Common with pregnancy

Question 22

Describe Normal Breast Histology

Answer 22

Looks like a tree with wide stroma on the outside and neatly organized ducts

Question 23

Fibroadenoma vs Cyst appearance on Imaging?

Answer 23

• Cyst is all black (anechoic)
• Fibro adenoma has grays

Question 24

Ductal Carcinoma In situ has many micro-calcifications and what what key histo presentation?

Answer 24

Central Necrosis (Comedo)

Question 25

Why does Paget's Breast Disease present with Eczematous skin and swelling?

Answer 25

Epidermal Junction Disruption

Question 26

2 Key clinical findings of Inflammatory Breast Cancer

Answer 26

1. Orange Peel 2. Redness

Question 27

Papillomas, sclerosing adenosis, Fibroadenomas, and a Phylloides tumor all share what in common in regards to breast pathology?

Answer 27

Proliferative Breast Disease

Question 28

Redness, induration, fever, chills in a young breast would make you think ______ whereas in a old breast you would think \_\_\_\_\_

Answer 28

- Mastitis (infection) - Cancer

Question 29

What risk do Non-proliferative Breast changes such as Simple Cysts, Fibrosis, Apocrine Metaplasia, and Adenosis have towards cancer?

Answer 29

None