bri thinks important

Question 1

CYP inhibitors

Answer 1

CRACK AMIGOS Ciprofloxacin Ritonavir Amiodorone Cimetidine Ketoconazole Acute alch use Macrolides Isoniazid Grapefruit juice Omeprazole Sulfonamide

Question 2

CYP inducers

Answer 2

Guinness, Corona, PBCS Chronic Alchism Griseofulvin Carbamazepine Phenytoin Benzos Rifampin St johns wort Chronic alchism

Question 3

antedotes for

Answer 3

Question 4

CO =

Answer 4

CO = SVxHR

Question 5

fick principle =

Answer 5

rt O2 consumption / (arterial O2 content)(venous O2 content)

Question 6

EF =

Answer 6

SV / EDV

Question 7

MAP =

Answer 7

P = QxR

MAP = CO x resistance

=2/3diastolic + 1/3 systolic

Question 8

pulse pressure =

Answer 8

systolic p - diastolic p

Question 9

Downs synd

• symp
• increased risk for
• hormone levels in utero
• US
• d/t

Answer 9

• intellectual disability, flat facies, prominent epicanthial folds, simean crease
• duodenal atresia, endocardial cushio defects, ALL, AML, Alz, polycythemia
• decr AFP, incr bhcg, decr estriol, incr inhibin A
• US: nuchal translucency
• d/t maternal nondisjunction of homologs during anaphase of meiosis 1

Question 10

Edwards synd

• which trisomy
• present
• hormones in utero

Answer 10

• 18
• intellectual disability, rocker bottom feet, micrognathia, clenched hands, prominent occiput
• decr bhcg, AFP, estriol, nml inhibin A

Question 11

PAtau synd

• which trisomy
• present
• hormones in utero
• US

Answer 11

• 13
• intellectual disability, rocker bottom feet, microcephaly, cleft lip and palate, holoprosencephaly, polydactyly, congenital <3 dis
• decr bhcg and PAPP-A
• nuchal translucency

Question 12

Ad dis’s

Answer 12

• ADPKD
• achondroplasia
• FAP
• gardner synd
• familial hypercholesterolemia
• hereditary hemorrhagiv telangiectaisa
• hereidtary spherocytosis
• HD
• marfans
• MENs
• NF1, 2
• Tuberous sclerosis
• vHL

Question 13

trimuc reapeat dis’s

Answer 13

• fragile x synd
• friendrich ataxia

Question 14

Renal clearance eqn and what substances used to estimate

Answer 14

= (U x V) / P

• U = urine conc
• V = urine flow rt
• p = plasma conc

inulin tells clearance, Cr is what we use to estimate

Question 15

Renal plasma flow eqn and what we use to estimate

Answer 15

= (Upah x V) / Ppah

• v = urine flow rt

Question 16

filtration fcration equ

Answer 16

= GFR/RPF

Question 17

excreation rt eqn

Answer 17

= Urine conc x urine flow rt

Question 18

filtered load eqn

Answer 18

= GFR x P

• p = plasma conc substance