C: 5-7

Question 1

HSV,CMV,VZV,H.Flu

Answer 1

Acyclovir
Valcyclovir is prodrug of Gancyclovir
Gancyclovir can cause bone marrow suppression
Cidofovir- inhib. viral DNA pol. HSV!
Foscarnet- same. 2nd line CMV
Oseltamivir
Palivizumab
Ribavirin

Question 2

Acyclovir MOA

Answer 2

Monophosph. by viral Thymidine Kinase
Incorp into DNA
Lack 3’ -OH

Question 3

Gancyclovir MOA

Answer 3

UL96 Kinase

CMV!

Question 4

Cidofovir MOA

SE

Answer 4

Cytidine analog

Nephrotoxic- give with probenecid

Question 5

Antiretroviral

Answer 5

NRTI's:
Ziduvodine
Lamivudine- Least potent, Also for Hep. B
Emtricitabine
Abacavir- Guanosine analog
Tenofovir- nucleotide. Also for Hep C

NNRTI’s:
Etravirine. אתרע מזלו

Question 6

Resistamce to NRTI

Answer 6

Mutation to pol gene

Question 7

Which NRTI can cause Fanconi’s syndrome?

Answer 7

Tenofovir

Question 8

Protease inhib.

Answer 8

Ritonavie
Darunavir
Lopinavir

ריטה דרה בלופט

Question 9

Which drug can inhibit CYP450?

Answer 9

Ritonavir

ריטה גדולה מהחיים

Question 10

Integrase inhib

Fusion inhib

Answer 10

Elvitegravir

Maraviroc

Question 11

Ribavirin SE

Answer 11

Hemolytic anemia

Question 12

Agents against hepatitis

Answer 12

INF-a- JAK STAT. Flu like symp.
Entecavir inhibits DNA pol
Tenofovir is nucleotide analog

Direct acting antivirals:
Paritaprevir
Grazoprevir
Sofosbuvir
Dasabuvir
Velpatasvir
Elbasvir