C. Diff

Question 1

True or false: Metronidazole should not be co-administered with vancomycin in any case of C. diff

Answer 1

False. Combined for fulminant C. diff episodes

Question 2

Which vancomycin dosing strategy is associated with the lowest recurrence rates?

Answer 2

Taper + pulse dosing

Question 3

What is bezlotoxumab?

Answer 3

Fully human IgG1 monoclonal antibody that binds to C. diff toxin B and prevents its effects on epithelial cells

Question 4

Rifaximin chaser protocol

Answer 4

After initial CDI treatment, rifaximin 400mg BID x 14 days

Question 5

Place in therapy of fecal transplant or ser-109 administration

Answer 5

Replace normal flora to restore balance. Ser-109 has much more organisms and more competitive organisms than a regular probiotic