Caffrey

Question 1

Common Features of Neglected Tropical Diseases

Answer 1

1. ) Tens to hundreds of millions infected
2. ) Affects disadvantaged communities
3. ) Have a relatively stable endemic foci
4. ) Often overlap geographically – increasing the risk of multiple infections
5. ) Can be lethal without treatment
6. ) Most often morbid
7. ) Increases risk of or damage by other infections
8. ) Causes stigma and discrimination
9. ) Can lead to mental health issues

Question 2

Features of Neglected Tropical Diseases with Respect to Drugs

Answer 2

1. ) No vaccines
2. ) Problems with existing drug; not many of them, have been around a long time, variable effects, toxicity, require clinical oversight, threat of resistance
3. Lack of investment in new drugs; no paying customers but PR can drive companies efforts

Question 3

Schistosomiasis

Answer 3

Flatworm infection, >200 million infected
- Drug = praziquantel (R enantiomer), (know structure slide 17, chiral center)

Good

• Single oral dose
• Active against all species of schistosomes
• Safe in first trimester and lactation

Bad

• Rarely offers complete cure
• Best against adult worms, younger worms far less susceptible

Any new drug must engage the target product profile!