Cancers

Question 1

erb-B2 (over-expression)

Answer 1

Breast, ovarian, lung, and stomach cancers

Question 2

N-myc (over-expression)

Answer 2

Neuroblastoma & small cell carcinoma of lung

Question 3

L-myc (over-expression)

Answer 3

Small cell carcinoma of lung

Question 4

int-2 (over-expression)

Answer 4

Bladder cancer, breast cancer, melanoma

Question 5

cyclin D (over-expression)

Answer 5

Breast, liver, esophageal cancers

Question 6

t(14;18) translocation

Answer 6

• seen in 80-90% of Follicular Lymphomas (and other non-Hodgkin’s lymphomas)
• B-cell tumor
• Results in BCL-2 overexpression → cancer

Question 7

t(9;22) rearrangement

Answer 7

Chronic Myelogenous Leukemia (CML)
(& Acute Lymphoblastic Leukemia [ALL])

• BCR-ABL fusion gene directs synthesis of constitutively active Tyrosine Kinase → cancer

Question 8

t(8:14) translocation

Answer 8

• Burkitt Lymphoma
• C-MYC gene translocation
• diffuse population of medium-sized lymphocytes w/ “starry sky” appearance

Question 9

fms (point mutation)

Answer 9

Myelodysplastic syndrome

Question 10

ret (point mutation)

Answer 10

MEN (multiple endocrine neoplasia) 2A and B, familial medullary thyroid carcinoma

Question 11

ras (point mutation)

Answer 11

Lung, colon, pancreas, leukemias

Question 12

t(11,14)

Answer 12

Mantle Cell Lymphoma

- Cyclin D gene translocation

Question 13

Tumor Suppressor mutation on Chromosome 5q

Answer 13

APC: colorectal cancer, pancreatic cancer, melanoma, familial adenomatous polyposis

Question 14

Tumor Suppressor mutation on Chromosome 9p

Answer 14

p16: melanoma

Question 15

Tumor Suppressor mutation on Chromosome 11p

Answer 15

WT1: Wilm’s tumor

Question 16

Tumor Suppressor mutation on Chromosome 13q

Answer 16

Rb: retinoblastoma, osteosarcoma, carcinoma of breast, colon, lung

BRCA2: carcinomas of male & female breast

Question 17

Tumor Suppressor mutation on Chromosome 17q

Answer 17

NF1: neurofibromatosis type 1

BRCA1: carcinoma of female breast and ovarian cancer

Question 18

Tumor Suppressor mutation on Chromosome 17

Answer 18

p53: Li-Fraumeni syndrome, most human cancers, multiple carcinomas and sarcomas

Question 19

Tumor Suppressor mutation on Chromosome 18q

Answer 19

DPC: pancreatic cancer

DCC: colon cancer

Question 20

Tumor Suppressor mutation on Chromosome 22q

Answer 20

NF2: neurofibromatosis type 2