Cannabinoids

Question 1

Eicosanoid synthesis

Answer 1

from fatty acid precursors like arachidonic acid or other 20 Carbon chains

Question 2

Prostanoids types

Answer 2

prostaglandins
thromboxanes

Question 3

leukotrienes

Answer 3

type of eicosanoid

Question 4

Lipooxygenases

Answer 4

produce leukotrienes from arachidonic acid

Question 5

COX 2

Answer 5

inducible from of COX found on immune cells

Question 6

epoxygenases /P450

Answer 6

enzymes that produce epoxyeicosatrienoic acids from arachidonic acid

Question 7

PGH2

Answer 7

Common prostaglandin from COX enzymes that differentiates to other forms

Question 8

PGI2

Answer 8

Prostacyclin
-main anti clotting factor in body produced by endothelial cells
-vaso dilator

Question 9

TXA2

Answer 9

Thromboxane
-produced in platelets it’s a pro clotting factor and vasoconstrictor

Question 10

PGD2

Answer 10

prostanoid
-vasodilation
-inhibits clotting
-relaxes GI/Uterus

Question 11

PGE2

Answer 11

Main inflammatory prostanoid
-vasodilation
-pyrogenic
-lung and GI SM effects (receptor dependant)

Question 12

PGF2 alpha

Answer 12

Prostanoid
-uterine contraction

Question 13

LTB4

Answer 13

leukotriene receptor
-pro inflammatory
-chemotaxis
-proliferation
-cytokine production

Question 14

CysLT

Answer 14

leukotriene receptor
-contracts bronchial muscle
-vasodilation
-coronary constriction

Question 15

THC subjective effects

Answer 15

-Relaxation
-sharpened senses
-psychoimetic effects

Question 16

THC Objective effects

Answer 16

-Impaired memory
-imparied motor control
-catalepsy
-analgesia
-antiemetic
-increase appetite

Question 17

THC peripheral effects

Answer 17

-Vasodilation (in eye, blood shot)
-decrease eye pressure
-bronchodilation

Question 18

CB1 receptor

Answer 18

Gi/o linked causing hyperpolization (inhibit Ca2+, activate K+ channels)
-Pre synaptic and prevent NT release
-found in endothelial cells, adipocytes, peripheral fevers

Question 19

CB2 receptor

Answer 19

Gi/o linked
found on immune cells

Question 20

Endocannabionoid action

Answer 20

act as retrograde transmitters to stop activation (released from post synaptic neuron acting on pre synaptic CB1 receptors)