Cardiogenetics

Question 1

[Gen/Card]

Which syndrome?
ST segment abnormalities in leads V1-V3 on EKG and a high risk for ventricular arrhythmias, family history of sudden cardiac death, SIDS

Answer 1

Brugada Syndrome
(Sudden Unexpected Nocturnal Death Syndrome)

Question 2

[Gen/Card/Brugada]

Brugada Syndrome
Most common gene?

Answer 2

SCN5A (30%)
and many other genes (CACNA1C, KCND3…)

Question 3

Brugada Syndrome
Inheritance pattern?

Answer 3

AD
except KCNE5 XL